Overcoming β-lactam resistance in Gram-negative pathogens
نویسندگان
چکیده
منابع مشابه
Β-lactam Resistance Genes in Gram Negative Bacteria Isolated from a Stream in Porto Alegre
The Dilúvio stream is part of an important watershed in the city of Porto Alegre, southern Brazil. It receives rain runoffs and domestic and hospital sewage, which carries a highly diverse microbial population. Some of these microorganisms may show resistance to different antimicrobials, acting as disseminators of resistance genes. This study characterizes the Gram-negative population present i...
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Objectives β-Lactams are commonly used for nosocomial infections and resistance to these agents among Gram-negative bacteria is increasing rapidly. Optimized dosing is expected to reduce the likelihood of resistance development during antimicrobial therapy, but the target for clinical dose adjustment is not well established. We examined the likelihood that various dosing exposures would suppres...
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The emergence of multidrug-resistant organisms coupled with an alarming scarcity of new antibiotic classes in the pipelines of the pharmaceutical industry has forced the healthcare community to optimize the therapeutic potential of currently available antibiotics. The primary determinant of -lactam efficacy is the duration of time in which the nonprotein-bound drug concentration (fT) exceeds th...
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1 Drug Resistance Proteomics Laboratory, Center for Antibiotic Resistance, Department of Biological Sciences, Myongji University, Yongin, Gyeonggido, Republic of Korea, 2 Department of Laboratory Medicine and Research Institute of Bacterial Resistance, Yonsei University College of Medicine, Republic of Korea, 3 Structural Biology Laboratory, Marine Biotechnology Center, Korea Ocean Research and...
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ژورنال
عنوان ژورنال: Future Medicinal Chemistry
سال: 2016
ISSN: 1756-8919,1756-8927
DOI: 10.4155/fmc-2016-0076